On The Origin of Species by Charles Darwin Chapter 1 Page 4

“Variation under Domestication,” there are two factors: namely, the nature of the organism and the nature of the conditions. The former seems to be much the more important; for nearly similar variations sometimes arise under, as far as we can judge, dissimilar conditions; and, on the other hand, dissimilar variations arise under conditions which appear to be nearly uniform. The effects on the offspring are either definite or in definite. They may be considered as definite when all or nearly all the offspring of individuals exposed to certain conditions during several generations are modified in the same manner. It is extremely difficult to come to any conclusion in regard to the extent of the changes which have been thus definitely induced.

There can, however, be little doubt about many slight changes, such as