On The Origin of Species by Charles Darwin Chapter 6 Page 89

the law of homologous variation, the front limbs and the head would probably be affected. The shape, also, of the pelvis might affect by pressure the shape of certain parts of the young in the womb. The laborious breathing necessary in high regions tends, as we have good reason to believe, to increase the size of the chest; and again correlation would come into play. The effects of lessened exercise, together with abundant food, on the whole organisation is probably still more important, and this, as H. von Nathusius has lately shown in his excellent Treatise, is apparently one chief cause of the great modification which the breeds of swine have undergone.

But we are far too ignorant to speculate on the relative importance of the several known and unknown causes of variation; and I have made these remarks only to show