On The Origin of Species by Charles Darwin Chapter 9 Page 41

unknown differences in their reproductive systems. These differences in both cases follow, to a certain extent, as might have been expected, systematic affinity, by which term every kind of resemblance and dissimilarity between organic beings is attempted to be expressed. The facts by no means seem to indicate that the greater or lesser difficulty of either grafting or crossing various species has been a special endowment; although in the case of crossing, the difficulty is as important for the endurance and stability of specific forms as in the case of grafting it is unimportant for their welfare.

4. Origin And Causes Of The Sterility Of First Crosses And Of Hybrids

At one time it appeared to me probable, as it has to others, that the sterility of first crosses and of hybrids might have