On The Origin of Species by Charles Darwin Chapter 9 Page 57

life are beneficial to all living things. We see this acted on by farmers and gardeners in their frequent exchanges of seed, tubers, etc., from one soil or climate to another, and back again.

During the convalescence of animals, great benefit is derived from almost any change in their habits of life. Again, both with plants and animals, there is the clearest evidence that a cross between individuals of the same species, which differ to a certain extent, gives vigour and fertility to the offspring; and that close interbreeding continued during several generations between the nearest relations, if these be kept under the same conditions of life, almost always leads to decreased size, weakness, or sterility.

Hence it seems that, on the one hand, slight changes in the conditions of life